Article
Co-operative additive effects between HLA alleles in control of HIV-1.
PloS one - 1 Jan 2012
Matthews Philippa C, Listgarten Jennifer, Carlson Jonathan M, Payne Rebecca, Huang Kuan-Hsiang Gary, Frater John, Goedhals Dominique, Steyn Dewald, van Vuuren Cloete, Paioni Paolo, Jooste Pieter, Ogwu Anthony, Shapiro Roger, Mncube Zenele, Ndung'u Thumbi, Walker Bruce D, Heckerman David, Goulder Philip J R
Abstract excerpt
BACKGROUND: HLA class I genotype is a major determinant of the outcome of HIV infection, and the impact of certain alleles on HIV disease outcome is well studied. Recent studies have demonstrated that certain HLA class I alleles that are in linkage disequilibrium, such as HLA-A*74 and HLA-B*57, appear to function co-operatively to result in greater immune control of HIV than mediated by either single allele...
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