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Article

HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses.

PLoS pathogens - 1 Aug 2015

Erdmann Nathan, Du Victor Y, Carlson Jonathan, Schaefer Malinda, Jureka Alexander, Sterrett Sarah, Yue Ling, Dilernia Dario, Lakhi Shabir, Tang Jianming, Sidney John, Gilmour Jill, Allen Susan, Hunter Eric, Heath Sonya, Bansal Anju, Goepfert Paul A

Abstract excerpt

Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating escape; however, the ability of CD4+ T cells to exert selective pressure remains unclear. Using a computational approach on HIV gag/pol/nef sequences and HLA-II allelic data, we identified 29 HLA-II associated HIV sequence polymorphisms or...

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Share to CD4-Positive T-Lymphocytes
Share to Enzyme-Linked Immunospot Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class II

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Source

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Identifiers

PMID: 26302050
DOI: 10.1371/journal.ppat.1005111
PMCID: PMC4547780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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