Article
Atlas of nascent RNA transcripts reveals tissue-specific enhancer to gene linkages.
BMC genomics - 25 Apr 2025
Sigauke Rutendo F, Sanford Lynn, Maas Zachary L, Jones Taylor, Stanley Jacob T, Townsend Hope A, Allen Mary A, Dowell Robin D
Abstract excerpt
Gene transcription is controlled and modulated by regulatory regions, including enhancers and promoters. These regions are abundant in non-coding bidirectional transcription that results in generally unstable RNA. Using nascent RNA transcription data across hundreds of human samples, we identified over 800,000 regions containing bidirectional transcription. We then identify tissue specific, highly correlated...
Read the complete abstract on PubMedTopics
- Humans
- Enhancer Elements, Genetic
- Organ Specificity
- Transcription, Genetic
- Databases, Genetic
- Polymorphism, Single Nucleotide