Article

Profiling of transcribed <i>cis</i> -regulatory elements in single cells

2021-04-04

Abstract excerpt

Profiling of cis -regulatory elements (CREs, mostly promoters and enhancers) in single cells allows the interrogation of the cell-type and cell-state-specific contexts of gene regulation and genetic predisposition to diseases. Here we demonstrate single-cell RNA-5′end-sequencing (sc-end5-seq) methods can detect transcribed CREs (tCREs), enabling simultaneous quantification of gene expression and enhancer activiti...

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Literature Corpus work: 010f5a27-5c63-5f86-b041-7343cb45d316
DOI: 10.1101/2021.04.04.438388

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