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Article

Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell.

Diabetologia - 1 Nov 2023

Thompson Peter J, Pipella Jasmine, Rutter Guy A, Gaisano Herbert Y, Santamaria Pere

Abstract excerpt

Type 1 diabetes results from the poorly understood process of islet autoimmunity, which ultimately leads to the loss of functional pancreatic beta cells. Mounting evidence supports the notion that the activation and evolution of islet autoimmunity in genetically susceptible people is contingent upon early life exposures affecting the islets, especially beta cells. Here, we review some of the recent advances and...

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Identifiers

PMID: 37488322
DOI: 10.1007/s00125-023-05970-z
PMCID: PMC10542715

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