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Article

The perfect storm: unraveling the interplay of genetic predisposition and viral triggers in type 1 diabetes pathogenesis.

Frontiers in endocrinology - 1 Jan 2025

Veronese-Paniagua Daniel A, Millman Jeffrey R

Abstract excerpt

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the T cell-mediated destruction of insulin-secreting pancreatic β cells, leaving patients reliant on exogenous insulin to establish normoglycemia. Despite advancements in glucose management, the precise pathological mechanisms linking genetic predisposition and environmental triggers to the loss of immune tolerance remain incompletely...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41480350
DOI: 10.3389/fendo.2025.1734431
PMCID: PMC12753326

Genes

CD4
IFIH1
TYK2

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