Spontaneous single-nucleotide substitutions and microsatellite mutations have distinct distributions of fitness effects.

Abstract excerpt

The fitness effects of new mutations determine key properties of evolutionary processes. Beneficial mutations drive evolution, yet selection is also shaped by the frequency of small-effect deleterious mutations, whose combined effect can burden otherwise adaptive lineages and alter evolutionary trajectories and outcomes in clonally evolving organisms such as viruses, microbes, and tumors. The small effect sizes...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetic Fitness
• Share to Microsatellite Repeats