Article
High-resolution lineage tracking reveals travelling wave of adaptation in laboratory yeast.
Nature - 1 Nov 2019
Nguyen Ba Alex N, Cvijović Ivana, Rojas Echenique José I, Lawrence Katherine R, Rego-Costa Artur, Liu Xianan, Levy Sasha F, Desai Michael M
Abstract excerpt
In rapidly adapting asexual populations, including many microbial pathogens and viruses, numerous mutant lineages often compete for dominance within the population1-5. These complex evolutionary dynamics determine the outcomes of adaptation, but have been difficult to observe directly. Previous studies have used whole-genome sequencing to follow molecular adaptation6-10; however, these methods have limited...
Topics
- Adaptation, Physiological
- Cell Lineage
- Clone Cells
- DNA Barcoding, Taxonomic
- Evolution, Molecular
- Genetic Fitness
- Laboratories
- Mutation
- Saccharomyces cerevisiae