Spontaneous mutation rate and spectrum are modulated by organismal fitness.

Abstract excerpt

Understanding the principles governing mutagenesis is important because mutations are a fundamental driver of evolution and a cause of disease. Although mutation rates and spectra depend on genotype and environment, how these factors interact is unclear. We address this question using mutation accumulation experiments in 11 budding yeast strains across three environments that produce strong...

Topics

• Genetic Fitness
• Mutation Rate
• Selection, Genetic
• Mutation
• Saccharomyces cerevisiae
• Evolution, Molecular