Article
Precise estimates of mutation rate and spectrum in yeast.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jun 2014
Zhu Yuan O, Siegal Mark L, Hall David W, Petrov Dmitri A
Abstract excerpt
Mutation is the ultimate source of genetic variation. The most direct and unbiased method of studying spontaneous mutations is via mutation accumulation (MA) lines. Until recently, MA experiments were limited by the cost of sequencing and thus provided us with small numbers of mutational events and therefore imprecise estimates of rates and patterns of mutation. We used whole-genome sequencing to identify nearly...
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