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Article

Genome destabilizing mutator alleles drive specific mutational trajectories in Saccharomyces cerevisiae.

Genetics - 1 Feb 2014

Stirling Peter C, Shen Yaoqing, Corbett Richard, Jones Steven J M, Hieter Philip

Abstract excerpt

In addition to environmental factors and intrinsic variations in base substitution rates, specific genome-destabilizing mutations can shape the mutational trajectory of genomes. How specific alleles influence the nature and position of accumulated mutations in a genomic context is largely unknown. Understanding the impact of genome-destabilizing alleles is particularly relevant to cancer genomes where biased...

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Identifiers

PMID: 24336748
DOI: 10.1534/genetics.113.159806
PMCID: PMC3914614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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