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Contribution of Spontaneous Mutations to Quantitative and Molecular Variation at the Highly Repetitive rDNA Locus in Yeast.

Genome biology and evolution - 6 Oct 2023

Sharp Nathaniel P, Smith Denise R, Driscoll Gregory, Sun Kexin, Vickerman Catherine M, Martin Sterling C T

Abstract excerpt

The ribosomal DNA array in Saccharomyces cerevisiae consists of many tandem repeats whose copy number is believed to be functionally important but highly labile. Regulatory mechanisms have evolved to maintain copy number by directed mutation, but how spontaneous variation at this locus is generated and selected has not been well characterized. We applied a mutation accumulation approach to quantify the impacts of...

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Identifiers

PMID: 37847861
DOI: 10.1093/gbe/evad179
PMCID: PMC10581546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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