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Article

Structures of three HIV-1 HLA-B*5703-peptide complexes and identification of related HLAs potentially associated with long-term nonprogression.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2005

Stewart-Jones Guillaume B E, Gillespie Geraldine, Overton Ian M, Kaul Rupert, Roche Philippe, McMichael Andrew J, Rowland-Jones Sarah, Jones E Yvonne

Abstract excerpt

Long-term nonprogression during acute HIV infection has been strongly associated with HLA-B*5701 or HLA-B*5703. In this study, we present the high resolution crystal structures of HLA-B*5703 complexes with three HIV-1 epitopes: ISPRTLNAW (ISP), KAFSPEVIPMF (KAF-11), and KAFSPEVI (KAF-8). These reveal peptide anchoring at position 2 and their C termini. The different peptide lengths and primary sequences are...

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Identifiers

PMID: 16081817
DOI: 10.4049/jimmunol.175.4.2459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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