Article
Structures of three HIV-1 HLA-B*5703-peptide complexes and identification of related HLAs potentially associated with long-term nonprogression.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2005
Stewart-Jones Guillaume B E, Gillespie Geraldine, Overton Ian M, Kaul Rupert, Roche Philippe, McMichael Andrew J, Rowland-Jones Sarah, Jones E Yvonne
Abstract excerpt
Long-term nonprogression during acute HIV infection has been strongly associated with HLA-B*5701 or HLA-B*5703. In this study, we present the high resolution crystal structures of HLA-B*5703 complexes with three HIV-1 epitopes: ISPRTLNAW (ISP), KAFSPEVIPMF (KAF-11), and KAFSPEVI (KAF-8). These reveal peptide anchoring at position 2 and their C termini. The different peptide lengths and primary sequences are...
Topics
- Acute Disease
- Alleles
- Antigen Presentation
- Computational Biology
- Crystallography, X-Ray
- Disease Progression
- Epitopes, T-Lymphocyte
- HIV Core Protein p24
- HIV Infections
- HIV-1
- HLA-B Antigens
- Humans
- Hydrogen Bonding