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Article

Acquired Genetic and Epigenetic Variation in Human Pluripotent Stem Cells.

Advances in biochemical engineering/biotechnology - 1 Jan 2000

Kyriakides O, Halliwell J A, Andrews P W

Abstract excerpt

Human pluripotent stem cells (hPSCs) can acquire non-random genomic variation during culture. Some of these changes are common in tumours and confer a selective growth advantage in culture. Additionally, there is evidence that reprogramming of human induced pluripotent stem cells (hiPSCs) introduces mutations. This poses a challenge to both the safety of clinical applications and the reliability of basic research...

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PMID: 29071402
DOI: 10.1007/10_2017_22

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