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Article

Acquired genetic changes in human pluripotent stem cells: origins and consequences.

Nature reviews. Molecular cell biology - 1 Dec 2020

Halliwell Jason, Barbaric Ivana, Andrews Peter W

Abstract excerpt

In the 20 years since human embryonic stem cells, and subsequently induced pluripotent stem cells, were first described, it has become apparent that during long-term culture these cells (collectively referred to as 'pluripotent stem cells' (PSCs)) can acquire genetic changes, which commonly include gains or losses of particular chromosomal regions, or mutations in certain cancer-associated genes, especially TP53....

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Identifiers

PMID: 32968234
DOI: 10.1038/s41580-020-00292-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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