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Article

Mutational signature distribution varies with DNA replication timing and strand asymmetry.

Genome biology - 10 Sept 2018

Tomkova Marketa, Tomek Jakub, Kriaucionis Skirmantas, Schuster-Böckler Benjamin

Abstract excerpt

BACKGROUND: DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes. Here, we use somatic mutation signatures-each representing a mutagenic process-derived from 3056 patients spanning 19 cancer types to quantify the strand asymmetry of mutational signatures around replication origins and between early and late replicating regions. RESULTS:...

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Identifiers

PMID: 30201020
DOI: 10.1186/s13059-018-1509-y
PMCID: PMC6130095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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