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Article

Analysis of Evolutionary Conservation, Expression Level, and Genetic Association at a Genome-wide Scale Reveals Heterogeneity Across Polygenic Phenotypes.

Molecular biology and evolution - 3 Jul 2024

Giel Ann-Sophie, Bigge Jessica, Schumacher Johannes, Maj Carlo, Dasmeh Pouria

Abstract excerpt

Understanding the expression level and evolutionary rate of associated genes with human polygenic diseases provides crucial insights into their disease-contributing roles. In this work, we leveraged genome-wide association studies (GWASs) to investigate the relationship between the genetic association and both the evolutionary rate (dN/dS) and expression level of human genes associated with the two polygenic...

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PMID: 38865495
DOI: 10.1093/molbev/msae115
PMCID: PMC11247350

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