Article

Gene Interaction Network Architecture of Human Polygenic Traits Reveals Domain-Specific Connectivity and Evolutionary Pressures

2025-05-23

Abstract excerpt

Human polygenic phenotypes arise from complex interactions among genes within regulatory networks. To gain insights into the structural and evolutionary characteristics of these networks, we analyzed gene interaction networks across 4756 human polygenic phenotypes, contrasting the network properties of genes associated with polygenic phenotypes against those of non-associated genes. Our results indicate that genes...

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Literature Corpus work: e466620f-2120-5332-b9ed-19e9974efc87
DOI: 10.1101/2025.05.23.655809

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