Article

Common and rare genetic variants show network convergence for a majority of human traits

2025-06-28

Abstract excerpt

<h4>ABSTRACT</h4> While both common and rare variants contribute to the genetic etiology of complex traits, whether their impacts manifest through the same effector genes and molecular mechanisms is not well understood. Here, we systematically analyze common and rare variants associated with each of 373 phenotypic traits within a large biological knowledge network of gene and protein interactions. While common an...

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Literature Corpus work: 4bf0d8a3-6cd3-543b-a292-e48ad6b8d1a8
DOI: 10.1101/2025.06.27.25330419

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