Protein-protein interaction network architecture of human polygenic traits reveals domain-spanning connectivity and evolutionary pressures.

doi:10.1186/s13059-026-04253-1

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Article

Protein-protein interaction network architecture of human polygenic traits reveals domain-spanning connectivity and evolutionary pressures.

Genome biology - 27 Aug 2026

Tamandeh Ehsan, Kunwar Kiran, Bigge Jessica, Serohijos Adrian, Schumacher Johannes, Maj Carlo, Dasmeh Pouria

Abstract excerpt

BACKGROUND: Human polygenic phenotypes arise from the combined effects of many genes that interact within molecular networks. Yet, we know little about how the structure of these networks constrains or facilitates the evolution of complex traits. Here, we systematically examine the relationship between protein-protein interaction (PPI) network architecture and evolutionary signatures across 4,756 human polygenic...

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PMID: 42665836
DOI: 10.1186/s13059-026-04253-1
PMCID: PMC13523357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.