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Article

Ube2v1 Positively Regulates Protein Aggregation by Modulating Ubiquitin Proteasome System Performance Partially Through K63 Ubiquitination.

Circulation research - 27 Mar 2020

Xu Na, Gulick James, Osinska Hanna, Yu Yang, McLendon Patrick M, Shay-Winkler Kritton, Robbins Jeffrey, Yutzey Katherine E

Abstract excerpt

RATIONALE: Compromised protein quality control can result in proteotoxic intracellular protein aggregates in the heart, leading to cardiac disease and heart failure. Defining the participants and understanding the underlying mechanisms of cardiac protein aggregation is critical for seeking therapeutic targets. We identified Ube2v1 (ubiquitin-conjugating enzyme E2 variant 1) in a genome-wide screen designed to...

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Identifiers

PMID: 32081062
DOI: 10.1161/CIRCRESAHA.119.316444
PMCID: PMC7135969

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