E3 ubiquitin ligase TRIM21-mediated K48-linked ubiquitination of ALDH2 rs671 mutant promotes adverse cardiac remodeling.

doi:10.1172/jci.insight.197555

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

E3 ubiquitin ligase TRIM21-mediated K48-linked ubiquitination of ALDH2 rs671 mutant promotes adverse cardiac remodeling.

JCI insight - 8 Apr 2026

Han Tianrui, Wen Xin, Guo Yunyun, Zhao Xiangkai, Zhang Jian, Chen Yuguo, Xu Feng

Abstract excerpt

Heart failure (HF) persists as the primary cause of death among patients recovering from acute myocardial infarction (AMI). Protein ubiquitination has been implicated as a key modulator of HF pathogenesis, yet the role of ubiquitination in the Aldh2 rs671 mutant - the most common single-nucleotide variant in human populations - remains poorly understood. We discovered TRIM21 as a previously unrecognized E3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Dehydrogenase, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibrosis

Share to Heart Failure

Share to Myocardial Infarction

Share to Myocardium

Share to Ribonucleoproteins

Share to Ubiquitination

Share to Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 41734032
DOI: 10.1172/jci.insight.197555
PMCID: PMC13134731

Genes

ALDH2
TRIM21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E3 ubiquitin ligase TRIM21-mediated K48-linked ubiquitination of ALDH2 rs671 mutant promotes adverse cardiac remodeling.PMID 41734032Read ↗

Human Molecular Genetic and Functional Studies Identify <i>TRIM63</i> , Encoding Muscle RING Finger Protein 1, as a Novel Gene for Human Hypertrophic CardiomyopathySemantic proximity Read ↗

Emerging Role of TRIM Family Proteins in Cardiovascular DiseaseSemantic proximity Read ↗

The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosisSemantic proximity Read ↗

TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart FailureSemantic proximity Read ↗

The Role of UBE2-Conjugating Enzymes in the Mechanism of MuRF1 UbiquitylationSemantic proximity Read ↗

O-GlcNAcylation-Ubiquitin Crosstalk of METTL1 Drives m7G Epitranscriptomic Collapse and Lipid Metabolic Reprogramming in Diabetic CardiomyopathySemantic proximity Read ↗

Cardiac effects and clinical applications of MG53Semantic proximity Read ↗

Rare variants in genes encoding MuRF1 and MuRF2 are modifiers of hypertrophic cardiomyopathy.Semantic proximity Read ↗

SQSTM1/p62 UFMylation Enhances Autophagic Clearance of Pathogenic Mutant Huntingtin.Semantic proximity Read ↗

The role of post‐translational modifications in cardiac hypertrophySemantic proximity Read ↗

Histone H4K20 Trimethylation is Decreased in Murine Models of Heart DiseaseSemantic proximity Read ↗

Ube2v1 Positively Regulates Protein Aggregation by Modulating Ubiquitin Proteasome System Performance Partially Through K63 Ubiquitination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.