Article
Structural and functional insights into the roles of the Mms21 subunit of the Smc5/6 complex.
Molecular cell - 11 Sept 2009
Duan Xinyuan, Sarangi Prabha, Liu Xianpeng, Rangi Gurdish K, Zhao Xiaolan, Ye Hong
Abstract excerpt
The Smc5/6 complex is an evolutionarily conserved chromosomal ATPase required for cell growth and DNA repair. Its Mms21 subunit supports both functions by docking to the arm region of Smc5 and providing SUMO ligase activity. Here, we report the crystal structure of Mms21 in complex with the Smc5...
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