Article

Polyclonal-Monoclonal Transition in Lung Squamous Cell Carcinoma Evolution

2026-03-30

Abstract excerpt

The evolutionary trajectory of lung squamous cell carcinoma (LUSC) remains poorly defined, hindering the development of effective therapies. By integrating genomic and transcriptomic sequencing from human LUSC specimens, we delineated a polyclonal-to-monoclonal evolutionary trajectory during LUSC progression. This evolutionary pattern was corroborated by single-cell RNA sequencing, which revealed consistent tumor...

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Literature Corpus work: fc517ce4-e7d0-5048-8162-6d7ace61b43d
DOI: 10.64898/2026.03.27.714653

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