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Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts

19 Apr 2022

Abstract excerpt

Access to clinically relevant small cell lung cancer (SCLC) tissue is limited because surgical resection is rare in metastatic SCLC. Patient-derived xenografts (PDX) and circulating tumor cell-derived xenografts (CDX) have emerged as valuable tools to characterize SCLC. Here, we present a resource of 46 extensively annotated PDX/CDX models derived from 33 patients with SCLC. We perform multi-omic analyses, using...

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PMID: 35440124
DOI: 10.1038/s41467-022-29794-4

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