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Article

An isoform quantitative trait locus in SBNO2 links genetic susceptibility to Crohn's disease with defective antimicrobial activity.

Nature communications - 28 May 2024

Aschenbrenner Dominik, Nassiri Isar, Venkateswaran Suresh, Pandey Sumeet, Page Matthew, Drowley Lauren, Armstrong Martin, Kugathasan Subra, Fairfax Benjamin, Uhlig Holm H

Abstract excerpt

Despite major advances in linking single genetic variants to single causal genes, the significance of genetic variation on transcript-level regulation of expression, transcript-specific functions, and relevance to human disease has been poorly investigated. Strawberry notch homolog 2 (SBNO2) is a candidate gene in a susceptibility locus with different variants associated with Crohn's disease and bone mineral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38806456
DOI: 10.1038/s41467-024-47218-3
PMCID: PMC11133462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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