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Article

The Relationship Between CSF1R Signaling, Monocyte-Macrophage Differentiation, and Susceptibility to Inflammatory Bowel Disease.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2025

Hume David A, Summers Kim M, O'Brien Claire, Pavli Paul

Abstract excerpt

More than 300 genomic loci have been associated with increased susceptibility to inflammatory bowel disease (IBD) through genome-wide association studies. A major challenge in the translation of genome-wide association studies to mechanistic insights lies in connecting noncoding variants to function. For example, single-nucleotide variants (SNVs) in the vicinity of the gene encoding the transcription factor ETS2...

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Identifiers

PMID: 40154882
DOI: 10.1016/j.jcmgh.2025.101510
PMCID: PMC12143753

Genes

ETS2
CSF1
CSF1R
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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