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Article

Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease.

Gastroenterology - 1 Jan 2014

VanDussen Kelli L, Liu Ta-Chiang, Li Dalin, Towfic Fadi, Modiano Nir, Winter Rachel, Haritunians Talin, Taylor Kent D, Dhall Deepti, Targan Stephan R, Xavier Ramnik J, McGovern Dermot P B, Stappenbeck Thaddeus S

Abstract excerpt

BACKGROUND & AIMS: Genetic susceptibility loci for Crohn's disease (CD) are numerous, complex, and likely interact with undefined components of the environment. It has been a challenge to link the effects of particular loci to phenotypes of cells associated with pathogenesis of CD, such as Paneth cells. We investigated whether specific phenotypes of Paneth cells associated with particular genetic susceptibility...

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Source

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Identifiers

PMID: 24076061
DOI: 10.1053/j.gastro.2013.09.048
PMCID: PMC3899786

Genes

NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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