Article
Expression of ASC splice variant found in Japanese patients with palindromic rheumatism is regulated by rs8056505 single nucleotide polymorphism and interleukin-1 beta.
Asian Pacific journal of allergy and immunology - 1 Sept 2025
Hattori Masaya, Yabuuchi Atsuko, Tanaka Hayate, Kawara Taketo, Wang Hongyan, Inoue Koji, Shiozawa Shunichi, Komai Koichiro
Abstract excerpt
BACKGROUND: Palindromic rheumatism (PR) is an infrequent form of periodic arthritis. Based on the similarity of the pathogenesis of PR to autoinflammatory syndromes, we previously found that the dominant-active splice variant of the inflammasome adaptor protein, apoptosis-associated speck-like protein containing a CARD (ASC), which lacks exon 2 (Δexon2), is expressed in Japanese patients with PR. OBJECTIVE:...
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