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Article

The potential clinical impact of cell type-specific genetic regulation: Crohn's disease.

Clinical and translational medicine - 1 Nov 2023

Tyebally Rika, Xue Angli, Powell Joseph E

Abstract excerpt

Complex diseases are heterogenous due to variation in their genetic and environmental underpinnings, leading to varied treatment responses. Genome-wide association studies (GWAS) integrated with single-cell expression quantitative trait loci analyses (eQTL) can pinpoint cell-type specific candidate disease-relevant genes and pathways. This knowledge can be applied to patient stratification and novel therapeutic...

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Identifiers

PMID: 37983917
DOI: 10.1002/ctm2.1474
PMCID: PMC10659767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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