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Article

A Novel PTPN2 Isoform Differentially Regulates Immune Response.

European journal of immunology - 1 May 2026

Li Xiaoguang, Rahimov Fedik, Wang Rui, Gao Lei, Ma Renze, Han Tiankai, Bi Yingtao, Cruz Freidrich, Wang Jing, Grosskurth Shaun, Asque Elizabeth, Paez-Cortez Jesus, Levesque Marc C, Crosbie Nancy E, Radstake Timothy, Biswas Amlan, Katlinski Kanstantsin

Abstract excerpt

Genome-wide association studies implicate the PTPN2 gene locus (18p11.21) in risk for several autoimmune diseases, including inflammatory bowel disease. Through genetic fine mapping, we identified the single-nucleotide polymorphism rs80262450 in the PTPN2 gene as the putative causal variant. Analysis of GTEx tissue samples and genetically engineered myeloid cell lines carrying risk and nonrisk alleles of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42153603
DOI: 10.1002/eji.70207
PMCID: PMC13185683

Genes

PTPN2
NES
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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A Novel PTPN2 Isoform Differentially Regulates Immune Response.PMID 42153603Read ↗

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