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Article

Genetic Effects on Transcriptome Profiles in Colon Epithelium Provide Functional Insights for Genetic Risk Loci.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2021

Díez-Obrero Virginia, Dampier Christopher H, Moratalla-Navarro Ferran, Devall Matthew, Plummer Sarah J, Díez-Villanueva Anna, Peters Ulrike, Bien Stephanie, Huyghe Jeroen R, Kundaje Anshul, Ibáñez-Sanz Gemma, Guinó Elisabeth, Obón-Santacana Mireia, Carreras-Torres Robert, Casey Graham, Moreno Víctor

Abstract excerpt

BACKGROUND & AIMS: The association of genetic variation with tissue-specific gene expression and alternative splicing guides functional characterization of complex trait-associated loci and may suggest novel genes implicated in disease. Here, our aims were as follows: (1) to generate reference profiles of colon mucosa gene expression and alternative splicing and compare them across colon subsites (ascending,...

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Alternative Splicing
Colon
Epithelium
Genetic Associations and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic factors in colorectal cancer

Polymorphism, Single Nucleotide

Quantitative Trait Loci

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Open in PubMed Open full text

Identifiers

PMID: 33601062
DOI: 10.1016/j.jcmgh.2021.02.003
PMCID: PMC8102177

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