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Article

The PIK3CA gene as a mutated target for cancer therapy.

Current cancer drug targets - 1 Dec 2008

Gustin John P, Cosgrove David P, Park Ben Ho

Abstract excerpt

The development of targeted therapies with true specificity for cancer relies upon exploiting differences between cancerous and normal cells. Genetic and genomic alterations including somatic mutations, translocations, and amplifications have served as recent examples of how such differences can be exploited as effective drug targets. Small molecule inhibitors and monoclonal antibodies directed against the...

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Identifiers

PMID: 19075596
DOI: 10.2174/156800908786733504
PMCID: PMC2831175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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