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Article

Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes.

PLoS computational biology - 1 Feb 2020

Liu Chuang, Zhao Junfei, Lu Weiqiang, Dai Yao, Hockings Jennifer, Zhou Yadi, Nussinov Ruth, Eng Charis, Cheng Feixiong

Abstract excerpt

Tumor-specific genomic alterations allow systematic identification of genetic interactions that promote tumorigenesis and tumor vulnerabilities, offering novel strategies for development of targeted therapies for individual patients. We develop an Individualized Network-based Co-Mutation (INCM) methodology by inspecting over 2.5 million nonsynonymous somatic mutations derived from 6,789 tumor exomes across 14...

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Identifiers

PMID: 32101536
DOI: 10.1371/journal.pcbi.1007701
PMCID: PMC7062285

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