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Article

Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations.

Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Mar 2023

Sivakumar Smruthy, Jin Dexter X, Rathod Ruchita, Ross Jeffrey, Cantley Lewis C, Scaltriti Maurizio, Chen Jessica W, Hutchinson Katherine E, Wilson Timothy R, Sokol Ethan S, Vasan Neil

Abstract excerpt

PURPOSE: To comprehensively characterize tissue-specific and molecular subclasses of multiple PIK3CA (multi-PIK3CA) mutations and assess their impact on potential therapeutic outcomes. EXPERIMENTAL DESIGN: We profiled a pan-cancer cohort comprised of 352,392 samples across 66 tumor types using a targeted hybrid capture-based next-generation sequencing panel covering at least 324 cancer-related genes. Molecularly...

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Identifiers

PMID: 36595567
DOI: 10.1158/1078-0432.CCR-22-2270
PMCID: PMC10011881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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