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Article

A phosphoproteomic screen demonstrates differential dependence on HER3 for MAP kinase pathway activation by distinct PIK3CA mutations.

Proteomics - 1 Jan 2015

Blair Brian G, Wu Xinyan, Zahari Muhammad Saddiq, Mohseni Morassa, Cidado Justin, Wong Hong Yuen, Beaver Julia A, Cochran Rory L, Zabransky Daniel J, Croessmann Sarah, Chu David, Toro Patricia Valda, Cravero Karen, Pandey Akhilesh, Park Ben Ho

Abstract excerpt

The PIK3CA gene encodes for the p110 alpha isoform of PI3 kinase and is one of the most frequently mutated oncogenes in human cancers. However, the mechanisms by which PIK3CA mutations activate cell signaling are not fully understood. Here we used a phosphoproteomic approach to compare differential phosphorylation patterns between human breast epithelial cells and two isogenic somatic cell knock in derivatives,...

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Share to Class I Phosphatidylinositol 3-Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25367220
DOI: 10.1002/pmic.201400342
PMCID: PMC4352327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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