Article
Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations.
Cancer research - 15 Dec 2015
Dogruluk Turgut, Tsang Yiu Huen, Espitia Maribel, Chen Fengju, Chen Tenghui, Chong Zechen, Appadurai Vivek, Dogruluk Armel, Eterovic Agna Karina, Bonnen Penelope E, Creighton Chad J, Chen Ken, Mills Gordon B, Scott Kenneth L
Abstract excerpt
Large-scale sequencing efforts are uncovering the complexity of cancer genomes, which are composed of causal "driver" mutations that promote tumor progression along with many more pathologically neutral "passenger" events. The majority of mutations, both in known cancer drivers and uncharacterized genes, are generally of low occurrence, highlighting the need to functionally annotate the long tail of infrequent...
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