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Article

ABCB1 C1236T, G2677TA and C3435T Genetic Polymorphisms and Antidepressant Response Phenotypes: Results from a Portuguese Major Depressive Disorder Cohort.

International journal of molecular sciences - 8 May 2024

Santos Marlene, Lima Luis, Carvalho Serafim, Brandão Andreia, Barroso Fátima, Cruz Agostinho, Medeiros Rui

Abstract excerpt

P-glycoprotein (P-GP) is a transporter molecule expressed on the apical surface of capillary endothelial cells of the Blood-Brain Barrier (BBB), whose activity heavily influences drug distribution, including antidepressants. This transporter is encoded by ABCB1 gene, and genetic variations within ABCB1 gene have been proposed to affect drug efflux and have been previously associated with depression. In this...

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Identifiers

PMID: 38791151
DOI: 10.3390/ijms25105112
PMCID: PMC11120659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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