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Article

ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.

Progress in neuro-psychopharmacology & biological psychiatry - 15 Feb 2008

Kato Masaki, Fukuda Tsuyoshi, Serretti Alessandro, Wakeno Masataka, Okugawa Gaku, Ikenaga Yuka, Hosoi Yuka, Takekita Yoshiteru, Mandelli Laura, Azuma Junichi, Kinoshita Toshihiko

Abstract excerpt

Variability in antidepressant response is due to genetic and environmental factors. Among genetic factors, the ones controlling for availability of the drug at the target site are interesting candidates. Multidrug resistance 1 (ABCB1, MDR1) gene encodes a blood-brain barrier transporter P-glycoprotein that plays an important role in controlling the passage of substances between the blood and brain. In the present...

Read the complete abstract on PubMed

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder, Major

Share to Drug Resistance, Multiple

Share to Genes, MDR

Share to Paroxetine

Share to Selective Serotonin Reuptake Inhibitors

Share to Serotonin Plasma Membrane Transport Proteins

Source

Identifiers

PMID: 17913323
DOI: 10.1016/j.pnpbp.2007.09.003

Genes

ABCB1

Variants

rs1045642
rs1045642
rs1045642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.PMID 17913323Read ↗

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