Antidepressants and ABCB1 gene C3435T functional polymorphism: a naturalistic study.

doi:10.1159/000319361

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Antidepressants and ABCB1 gene C3435T functional polymorphism: a naturalistic study.

Neuropsychobiology - 1 Aug 2010

Menu Patrick, Gressier Florence, Verstuyft Céline, Hardy Patrick, Becquemont Laurent, Corruble Emmanuelle

Abstract excerpt

INTRODUCTION: Pharmacogenetic factors may explain some of the interindividual variability of response to antidepressants in depressed patients. We focused on P-glycoprotein (P-GP), whose expression depends on a functional polymorphism of the ABCB1 gene (C3435T variants: dbSNP: rs1045642), the 3435CC genotype being linked to a high level of P-GP expression. Acting as an efflux pump at the blood-brain barrier, P-GP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to Body Weight

Share to Depressive Disorder, Major

Share to ABCB1 gene

Share to Genotype

Share to Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 20664232
DOI: 10.1159/000319361

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antidepressants and ABCB1 gene C3435T functional polymorphism: a naturalistic study.PMID 20664232Read ↗

ABCB1 C3435T polymorphism is associated with susceptibility to major depression, but not with a clinical response to citalopram in a Turkish population.Semantic proximity Read ↗

The Influence of C3435T Polymorphism of the ABCB1 Gene on Genetic Susceptibility to Depression and Treatment Response in Polish Population - Preliminary Report.Semantic proximity Read ↗

ABCB1 C1236T, G2677TA and C3435T Genetic Polymorphisms and Antidepressant Response Phenotypes: Results from a Portuguese Major Depressive Disorder Cohort.Semantic proximity Read ↗

ABCB1 genotyping in the treatment of depression.Semantic proximity Read ↗

Effect of ABCB1 C3435T Polymorphism on Pharmacokinetics of Antipsychotics and Antidepressants.Semantic proximity Read ↗

Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study.Semantic proximity Read ↗

The clinical impact of ABCB1 polymorphisms on the treatment of psychiatric diseases.Semantic proximity Read ↗

Genetics and personalized medicine in antidepressant treatment.Semantic proximity Read ↗

The clinical application of ABCB1 genotyping in antidepressant treatment: a pilot study.Semantic proximity Read ↗

Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population.Semantic proximity Read ↗

[Characterisation of selected molecular mechanisms influencing pharmacokinetics and pharmacodynamics of antidepressants].Semantic proximity Read ↗

ABCB1 gene C3435T polymorphism and drug resistance in epilepsy: evidence based on 8,604 subjects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.