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Article

The clinical application of ABCB1 genotyping in antidepressant treatment: a pilot study.

CNS spectrums - 1 Apr 2014

Breitenstein Barbara, Scheuer Sandra, Pfister Hildegard, Uhr Manfred, Lucae Susanne, Holsboer Florian, Ising Marcus, Brückl Tanja M

Abstract excerpt

BACKGROUND: The gene product of the ABCB1 gene, the P-glycoprotein, functions as a custodian molecule in the blood-brain barrier and regulates the access of most antidepressants into the brain. Previous studies showed that ABCB1 polymorphisms predicted the response to antidepressants that are substrates of the P-gp, while the response to nonsubstrates was not influenced by ABCB1 polymorphisms. The aim of the...

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Source

Identifiers

PMID: 23880209
DOI: 10.1017/S1092852913000436

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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