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Article

Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study.

Journal of psychiatric research - 1 Feb 2016

Breitenstein Barbara, Scheuer Sandra, Brückl Tanja Maria, Meyer Jobst, Ising Marcus, Uhr Manfred, Holsboer Florian

Abstract excerpt

P-glycoprotein, encoded by the ABCB1 gene, functions as an ATP-driven efflux pump in the blood-brain barrier, extruding its substrates and thereby limiting their passage into the brain. ABCB1 polymorphisms predicted antidepressant drug response: Minor allele carriers of SNPs rs2032583 and rs2235015 had higher remission rates than major allele homozygotes. The aim of the current study was to evaluate an ABCB1...

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Source

Identifiers

PMID: 26704739
DOI: 10.1016/j.jpsychires.2015.11.010

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study.PMID 26704739Read ↗

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