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Article

ABCB1 gene variants and antidepressant treatment outcome: A meta-analysis.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2015

Breitenstein Barbara, Brückl Tanja Maria, Ising Marcus, Müller-Myhsok Bertram, Holsboer Florian, Czamara Darina

Abstract excerpt

The efflux pump P-glycoprotein (P-gp), a gene product of the ABCB1 gene, plays a pivotal role in the transfer of various molecules across the blood-brain barrier. P-gp protects the brain by selectively extruding its substrates, including certain antidepressive drugs, thereby limiting their uptake into the brain. Uhr et al. [2008] first showed that ABCB1 variants predicted the remission to antidepressants with...

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Share to Antidepressive Agents
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25847751
DOI: 10.1002/ajmg.b.32309

Genes

ABCB1

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