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Article

MDR1 gene polymorphism: therapeutic response to paroxetine among patients with major depression.

Progress in neuro-psychopharmacology & biological psychiatry - 1 Aug 2008

Mihaljevic Peles Alma, Bozina Nada, Sagud Marina, Rojnic Kuzman Martina, Lovric Mila

Abstract excerpt

The multidrug resistance transporter, P-glycoprotein (P-gp), encoded by polymorphic MDR1 (ABCB1) gene, is involved in efflux transport of several antidepressants and acts as a barrier to different exogenous noxa in the blood-brain barrier. MDR1 gene belongs to the best understood mediators of drug resistance. Different polymorphisms in MDR1 have been found to be connected with P-gp expression and function. The...

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Source

Identifiers

PMID: 18550244
DOI: 10.1016/j.pnpbp.2008.03.018

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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