Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation

20 Jan 2021

Abstract excerpt

T helper type 17 (Th17) cells have important functions in the pathogenesis of inflammatory and autoimmune diseases. Retinoid-related orphan receptor-γt (RORγt) is necessary for Th17 cell differentiation and functions. However, the transcriptional regulation of RORγt expression, especially at the enhancer level, is still poorly understood. Here we identify a novel enhancer of RORγt gene in Th17 cells, RORCE2....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Immunotherapy and Immune Responses
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33473108
DOI: 10.1038/s41467-020-20786-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiationPMID 33473108Read ↗

NFAT primes the human RORC locus for RORγt expression in CD4+ T cellsSemantic proximity Read ↗

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper CellsSemantic proximity Read ↗

A proximal enhancer regulates RORA expression during early human Th17 cell differentiation.Semantic proximity Read ↗

Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3Semantic proximity Read ↗

RORγt and RORα signature genes in human Th17 cellsSemantic proximity Read ↗

Critical roles of super-enhancers in the pathogenesis of autoimmune diseasesSemantic proximity Read ↗

Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitisSemantic proximity Read ↗

Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disordersSemantic proximity Read ↗

Genes associated with T helper 17 cell differentiation and functionSemantic proximity Read ↗

LncRNA STAT4-AS1 inhibited TH17 cells differentiation by targeting RORγt proteinSemantic proximity Read ↗

Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular MetabolismSemantic proximity Read ↗

Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.