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Article

NFAT primes the human RORC locus for RORγt expression in CD4+ T cells

16 Oct 2019

Abstract excerpt

Abstract T helper 17 (Th17) cells have crucial functions in mucosal immunity and the pathogenesis of several chronic inflammatory diseases. The lineage-specific transcription factor, RORγt, encoded by the RORC gene modulates Th17 polarization and function, as well as thymocyte development. Here we define several regulatory elements at the human RORC locus in thymocytes and peripheral CD4 + T lymphocytes, with...

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PMID: 31619674
DOI: 10.1038/s41467-019-12680-x

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