Article
Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes.
eLife - 24 May 2024
Yan Donghui, Hu Bowen, Darst Burcu F, Mukherjee Shubhabrata, Kunkle Brian W, Deming Yuetiva, Dumitrescu Logan, Wang Yunling, Naj Adam, Kuzma Amanda, Zhao Yi, Kang Hyunseung, Johnson Sterling C, Carlos Cruchaga, Hohman Timothy J, Crane Paul K, Engelman Corinne D, Lu Qiongshi
Abstract excerpt
Rich data from large biobanks, coupled with increasingly accessible association statistics from genome-wide association studies (GWAS), provide great opportunities to dissect the complex relationships among human traits and diseases. We introduce BADGERS, a powerful method to perform polygenic score-based biobank-wide association scans. Compared to traditional approaches, BADGERS uses GWAS summary statistics as...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.