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Article

Genetic risk in Alzheimer's disease.

NPJ systems biology and applications - 14 Feb 2026

Pan Yining, Cho Hwayoung, Lou Qian, Zhang Wei, Asken Breton, Song Qianqian

Abstract excerpt

Alzheimer's disease (AD) has a strong genetic predisposition. Genome-wide association studies have identified multiple risk loci, yet many non-coding variants remain uncharacterized. Machine learning-based polygenic risk scores (PRS) enhance prediction by modeling genetic epistasis and sex-specific risks. This review summarizes AD genetic risk factors, PRS methodologies, and ML-based AD risk prediction. It also...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41690978
DOI: 10.1038/s41540-026-00665-8
PMCID: PMC13022224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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