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A Single-Cell Atlas of DNA Methylation in Autism Spectrum Disorder Reveals Distinct Regulatory and Aging Signatures

2025-06-21

Abstract excerpt

Autism spectrum disorder (ASD) is a common, genetically and clinically heterogeneous neurodevelopmental condition. Despite this diversity, studies of postmortem brain tissue have revealed convergent molecular changes across the cortex, including reduced synaptic function in subsets of excitatory and inhibitory neurons and increased glial reactivity. Whether these features are reflected in cell type–specific epigen...

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Literature Corpus work: 3ff95fb8-0a3a-5be6-9c93-b074d1b620a0
DOI: 10.1101/2025.06.17.660162

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