Article

Autism in a dish: ES cell models of autism with copy number variations reveal cell-type-specific vulnerability

2022-02-02

Abstract excerpt

<h4>SUMMARY</h4> Human genetics has identified numerous single nucleotide variations (SNVs) and copy number variations (CNVs) associated with autism spectrum disorders (ASD) and other psychiatric disorders. However, the lack of standardized biological resources impedes understanding of the common pathophysiology of ASD. Here, using next-generation chromosome engineering based on the CRISPR/Cas9 system, we establi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 830b2bcf-7956-5e47-9273-14af9c59c999
DOI: 10.1101/2022.02.02.478766

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Autism in a dish: ES cell models of autism with copy number variations reveal cell-type-specific vulnerabilityDOI 10.1101/2022.02.02.478766Read

<i>In vivo</i> Perturb-Seq reveals neuronal and glial abnormalities associated with Autism risk genesSemantic proximity Read

Functional Neurogenomics to Dissect Disease Mechanisms Across Models.Semantic proximity Read

Recent advances in the neurogenomics of autism spectrum disorder.Semantic proximity Read

Single-cell brain organoid screening identifies developmental defects in autismSemantic proximity Read

Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genesSemantic proximity Read

Enhancer-targeted CRISPR-A rescues haploinsufficiency and mutant phenotypes in organoid models of autismSemantic proximity Read

Developmental convergence and divergence in human stem cell models of autism spectrum disorderSemantic proximity Read

Developmental convergence and divergence in human stem cell models of autism.Semantic proximity Read

Molecular and network disruptions in neurodevelopment uncovered by single cell transcriptomics analysis of <i>CHD8</i> heterozygous cerebral organoidsSemantic proximity Read

CRISPR-Enabled Functional Genomics in hPSC-Derived Neural Models for Autism Spectrum DisorderSemantic proximity Read

Identifying cell type specific driver genes in autism-associated copy number loci from cerebral organoidsSemantic proximity Read

Cerebral Organoids Containing an <i>AUTS2</i> Missense Variant Model MicrocephalySemantic proximity Read